Prevalence of fimA genotypes of Porphyromonas gingivalis and other periodontal bacteria in a Spanish population with chronic periodontitis

摘要

Objectives: The aim of this study was to determine the prevalence of the different\udfimA\udgenotypes of\udPorphyromonas gingivalis\udin adult Spanish patients with chronic periodontitis, patients with gingivitis and periodontally\udhealthy subjects, and the relationship between these genotypes and other periodontopathogenic bacteria.\udStudy design: Samples of subgingival plaque were taken from 86 patients (33 with chronic periodontitis, 16 with\udgingivitis, and 37 periodontally healthy) in the course of a full periodontal examination. PCR was employed to\uddetermine the presence of the 6\udfimA\udgenotypes of\udPorphyromonas gingivalis\ud(I-V and Ib) and of\udAggregatibacter\udactinomycetemcomitans, Tannerella forsythia\udand\udTreponema denticola.\udResults:\udPorphyromonas gingivalis fimA\udgenotypes II and Ib were present in significantly higher percentages in\udperiodontal patients (39.4% and 12.1% respectively) than in healthy or gingivitis subjects. The prevalence of\udTannerella forsythia, Treponema denticola\ud, and\udPorphyromonas gingivalis fimA\udgenotype IV was significantly higher\udin the group that presented bleeding greater than 30%. A positive correlation was found between\udPorphyromonas\udgingivalis fimA\udgenotype IV and\udTreponema denticola\ud.\udConclusions: A strong association between\udPorphyromonas gingivalis fimA\udgenotypes II and Ib and chronic periodontitis exists in the Spanish population. The most prevalent genotype in periodontal patients is II